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Synthetic Biology

DNA/RNA Nanotech

+1

Bio-Inspired DNA Origami: Programmable Nanomachines Pierce Cell Membranes

Aug 20, 2026

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5 min read

Bio-Inspired DNA Origami: Programmable Nanomachines Pierce Cell Membranes

A programmable DNA origami machine mechanically pierces membranes to create a temporary transport pathway.

Marco Lolaico
Marco Lolaico

Deep Tech Breakdowns

+1

Recoded E. coli: Constructive Bio Transforms Biomanufacturing with Synthetic Genomes

Aug 16, 2026

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8 min read

Recoded E. coli: Constructive Bio Transforms Biomanufacturing with Synthetic Genomes

A radically recoded bacterial genome creates room for non-canonical amino acids in biological production.

Marco Lolaico
Marco Lolaico

AI for Genome

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AI-Designed Phages: Machine Learning Creates Viral Genomes!

Aug 13, 2026

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6 min read

AI-Designed Phages: Machine Learning Creates Viral Genomes!

Genome language models generate complete phage genomes that can actually infect and kill bacteria.

Marco Lolaico
Marco Lolaico

DNA/RNA Nanotech

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AI-Designed DNA Origami: Generative AI Tackles Nanotech!

Aug 6, 2026

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5 min read

AI-Designed DNA Origami: Generative AI Tackles Nanotech!

By training on simulated DNA origami structures, AI learns to design complex geometries despite limited experimental data.

Marco Lolaico
Marco Lolaico

Deep Tech Breakdowns

+1

Polymer-Peptides Hybrids: Grove Biopharma Targets Undruggable Diseases!

Jul 26, 2026

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6 min read

Polymer-Peptides Hybrids: Grove Biopharma Targets Undruggable Diseases!

Grove Biopharma uses protein-like polymers to deliver peptides inside cells, opening the door to drug targets that have long been considered unreachable.

Marco Lolaico
Marco Lolaico

Synthetic Biology

+1

Protein Crystals: Programming Living Cells as Microreactors!

Jul 16, 2026

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5 min read

Protein Crystals: Programming Living Cells as Microreactors!

Researchers turned living cells into programmable microreactors that grow and functionalize protein crystals.

Marco Lolaico
Marco Lolaico

DNA/RNA Nanotech

+1

Parallel DNA Synthesis: Chips & Enzymes Speed Up Biotech!

Jul 9, 2026

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5 min read

Parallel DNA Synthesis: Chips & Enzymes Speed Up Biotech!

By combining semiconductor chips and enzymes, researchers synthesized dozens of different DNA sequences in parallel.

Marco Lolaico
Marco Lolaico

Deep Tech Breakdowns

+2

Cache DNA's Room-Temperature DNA Technology Explained!

Jul 5, 2026

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7 min read

Cache DNA's Room-Temperature DNA Technology Explained!

Analyzing Cache DNA's room-temperature nucleic acid preservation technology: what's validated, what's proprietary, and what we still don't know

Marco Lolaico
Marco Lolaico

DNA/RNA Nanotech

+1

Simplified Bacterial Cells: New Weapons Against Antibiotic-Resistant Superbugs!

Jun 25, 2026

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5 min read

Simplified Bacterial Cells: New Weapons Against Antibiotic-Resistant Superbugs!

Scientists turn chromosome-free bacterial particles into programmable weapons against antibiotic-resistant pathogens

Marco Lolaico
Marco Lolaico

Synthetic Biology

AI-Designed 19-Letter Cells: Rewriting Life's Protein Alphabet!

Jun 18, 2026

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5 min read

AI-Designed 19-Letter Cells: Rewriting Life's Protein Alphabet!

Researchers rebuilt ribosomal proteins with a reduced 19-amino-acid alphabet.

Marco Lolaico
Marco Lolaico

Synthetic Biology

+1

AI-Designed Protein Cages: Virus-Inspired Nanocages Unlocked!

Jun 11, 2026

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5 min read

AI-Designed Protein Cages: Virus-Inspired Nanocages Unlocked!

Virus-inspired design unlocks giant, programmable protein nanocages.

Marco Lolaico
Marco Lolaico

DNA/RNA Nanotech

+1

Synthetic Cell Reactors: DNA Nanopores Engineer Cell Chemistry!

Jun 4, 2026

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5 min read

Synthetic Cell Reactors: DNA Nanopores Engineer Cell Chemistry!

DNA nanopores coordinate transport, signaling, and chemistry inside artificial cells.

Marco Lolaico
Marco Lolaico

DNA/RNA Nanotech

+1

Designer RNA Nanostars: Programming Membraneless Organelles!

May 21, 2026

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5 min read

Designer RNA Nanostars: Programming Membraneless Organelles!

RNA nanostars assemble membraneless organelles with tunable composition and behavior.

Marco Lolaico
Marco Lolaico

Synthetic Biology

+1

AI-Designed Protein Switches: ML Creates Allosteric Biosensors!

May 14, 2026

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6 min read

AI-Designed Protein Switches: ML Creates Allosteric Biosensors!

Researchers turn AI-designed binders into allosteric protein switches, creating sensors, logic gates, and programmable cellular responses.

Marco Lolaico
Marco Lolaico

Synthetic Biology

Designed Protein Recorders: Cells Build 3D Memory!

May 7, 2026

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5 min read

Designed Protein Recorders: Cells Build 3D Memory!

A protein-based recorder grows 3D structures inside cells, turning transient signals into molecular "tree-rings" you can image later.

Marco Lolaico
Marco Lolaico

Synthetic Biology

Computer-Powered Virtual Cells: 4D Simulations Model Life at Molecular Level!

Apr 16, 2026

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5 min read

Computer-Powered Virtual Cells: 4D Simulations Model Life at Molecular Level!

A 4D whole-cell model simulates cellular processes across space and time with molecular detail.

Marco Lolaico
Marco Lolaico

DNA/RNA Nanotech

+1

Molecular Hard Drives: DNA Origami Rewrites Data Storage!

Apr 9, 2026

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10 min read

Molecular Hard Drives: DNA Origami Rewrites Data Storage!

DNA origami structures act as storage nodes, encoding data and connections at the nanoscale.

Marco Lolaico
Marco Lolaico

DNA/RNA Nanotech

+1

Synthetic DNA Cells: Synthetic Cytoskeleton Engineering!

Apr 2, 2026

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10 min read

Synthetic DNA Cells: Synthetic Cytoskeleton Engineering!

Synthetic DNA cells recreate the crowded and viscoelastic environment of the cytoplasm.

Marco Lolaico
Marco Lolaico

Drug Delivery

+1

mRNA-Launched Vaccines: mRNA and Protein Nanostructures for Immune Breakthrough!

Mar 19, 2026

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9 min read

mRNA-Launched Vaccines: mRNA and Protein Nanostructures for Immune Breakthrough!

mRNA-launched vaccines merge intracellular expression with the potency of protein nanostructures.

Marco Lolaico
Marco Lolaico

Synthetic Biology

Biological Quantum Sensors: Fluorescent Proteins Transform Biology!

Mar 12, 2026

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10 min read

Biological Quantum Sensors: Fluorescent Proteins Transform Biology!

Directed evolution converts a fluorescent protein into a genetically encoded quantum sensor.

Marco Lolaico
Marco Lolaico

DNA/RNA Nanotech

+1

Designer RNA Tiles: Programmable Nanostructures Inside Cell Nuclei!

Feb 19, 2026

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8 min read

Designer RNA Tiles: Programmable Nanostructures Inside Cell Nuclei!

Programmable RNA structures assemble inside living cell nuclei

Marco Lolaico
Marco Lolaico

Synthetic Biology

RNA TimeVaults: Capturing Cellular Decision Dynamics!

Feb 12, 2026

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9 min read

RNA TimeVaults: Capturing Cellular Decision Dynamics!

A molecular hard drive engineered to store RNA states in living cells.

Marco Lolaico
Marco Lolaico

Synthetic Biology

Sidewinder Rewrites DNA Assembly Rules With Designed DNA Junctions!

Feb 5, 2026

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10 min read

Sidewinder Rewrites DNA Assembly Rules With Designed DNA Junctions!

A new assembly method builds complex DNA without sequence or length constraints

Marco Lolaico
Marco Lolaico

Synthetic Biology

+1

AI-Designed DNA Binders: Machine Learning Crafts Novel Proteins!

Dec 18, 2025

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10 min read

AI-Designed DNA Binders: Machine Learning Crafts Novel Proteins!

Designing sequence-specific DNA-binding proteins entirely from scratch

Marco Lolaico
Marco Lolaico

DNA/RNA Nanotech

+1

DNA Origami Membranes: Molecular Mimicry Rewrites Cellular Architecture!

Dec 11, 2025

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10 min read

DNA Origami Membranes: Molecular Mimicry Rewrites Cellular Architecture!

Engineered DNA barrels self-organize into flexible monolayers that behave like synthetic membranes.

Marco Lolaico
Marco Lolaico
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Plenty of Room

Stay ahead in AI protein design, DNA nanotech & synthetic biology. Under 10 minutes a week. Read by 617 people shaping biotech!

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