Marco Lolaico

DNA nanotech researcher, writing Plenty of Room to always bring you the coolest papers!

Deep Tech Breakdowns

Recoded E. coli: Constructive Bio Transforms Biomanufacturing with Synthetic Genomes

Aug 16, 2026

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8 min read

Recoded E. coli: Constructive Bio Transforms Biomanufacturing with Synthetic Genomes

A radically recoded bacterial genome creates room for non-canonical amino acids in biological production.

Marco Lolaico

AI for Genome

AI-Designed Phages: Machine Learning Creates Viral Genomes!

Aug 13, 2026

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6 min read

AI-Designed Phages: Machine Learning Creates Viral Genomes!

Genome language models generate complete phage genomes that can actually infect and kill bacteria.

Marco Lolaico

DNA/RNA Nanotech

AI-Designed DNA Origami: Generative AI Tackles Nanotech!

Aug 6, 2026

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5 min read

AI-Designed DNA Origami: Generative AI Tackles Nanotech!

By training on simulated DNA origami structures, AI learns to design complex geometries despite limited experimental data.

Marco Lolaico

Genome Editing Tools

KNIT Genome Editing: A New Designed Tool for Safer Gene Therapy!

Jul 30, 2026

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6 min read

KNIT Genome Editing: A New Designed Tool for Safer Gene Therapy!

A new genome editing platform physically tethers donor DNA to Cas9 for safer and more efficient gene insertion for therapeutic applications.

Marco Lolaico

Deep Tech Breakdowns

Polymer-Peptides Hybrids: Grove Biopharma Targets Undruggable Diseases!

Jul 26, 2026

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6 min read

Polymer-Peptides Hybrids: Grove Biopharma Targets Undruggable Diseases!

Grove Biopharma uses protein-like polymers to deliver peptides inside cells, opening the door to drug targets that have long been considered unreachable.

Marco Lolaico

DNA/RNA Nanotech

DNA Origami Vaccines: Next-Gen Immune Response!

Jul 23, 2026

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5 min read

DNA Origami Vaccines: Next-Gen Immune Response!

A DNA origami scaffold organizes antigens and immune signals with nanometer precision for stronger and broader antiviral immune responses.

Marco Lolaico

Synthetic Biology

Protein Crystals: Programming Living Cells as Microreactors!

Jul 16, 2026

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5 min read

Protein Crystals: Programming Living Cells as Microreactors!

Researchers turned living cells into programmable microreactors that grow and functionalize protein crystals.

Marco Lolaico

DNA/RNA Nanotech

Parallel DNA Synthesis: Chips & Enzymes Speed Up Biotech!

Jul 9, 2026

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5 min read

Parallel DNA Synthesis: Chips & Enzymes Speed Up Biotech!

By combining semiconductor chips and enzymes, researchers synthesized dozens of different DNA sequences in parallel.

Marco Lolaico

Deep Tech Breakdowns

Cache DNA's Room-Temperature DNA Technology Explained!

Jul 5, 2026

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7 min read

Cache DNA's Room-Temperature DNA Technology Explained!

Analyzing Cache DNA's room-temperature nucleic acid preservation technology: what's validated, what's proprietary, and what we still don't know

Marco Lolaico

AI Protein Design

AI-Designed Metalloenzymes: Machine Learning Creates Nature-Level Catalysts!

Jul 2, 2026

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5 min read

AI-Designed Metalloenzymes: Machine Learning Creates Nature-Level Catalysts!

By combining quantum chemistry with generative AI, researchers designed metal-dependent enzymes that approach the efficiency of nature's own catalysts.

Marco Lolaico

DNA/RNA Nanotech

Simplified Bacterial Cells: New Weapons Against Antibiotic-Resistant Superbugs!

Jun 25, 2026

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5 min read

Simplified Bacterial Cells: New Weapons Against Antibiotic-Resistant Superbugs!

Scientists turn chromosome-free bacterial particles into programmable weapons against antibiotic-resistant pathogens

Marco Lolaico

Synthetic Biology

AI-Designed 19-Letter Cells: Rewriting Life's Protein Alphabet!

Jun 18, 2026

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5 min read

AI-Designed 19-Letter Cells: Rewriting Life's Protein Alphabet!

Researchers rebuilt ribosomal proteins with a reduced 19-amino-acid alphabet.

Marco Lolaico

Synthetic Biology

AI-Designed Protein Cages: Virus-Inspired Nanocages Unlocked!

Jun 11, 2026

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5 min read

AI-Designed Protein Cages: Virus-Inspired Nanocages Unlocked!

Virus-inspired design unlocks giant, programmable protein nanocages.

Marco Lolaico

DNA/RNA Nanotech

Synthetic Cell Reactors: DNA Nanopores Engineer Cell Chemistry!

Jun 4, 2026

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5 min read

Synthetic Cell Reactors: DNA Nanopores Engineer Cell Chemistry!

DNA nanopores coordinate transport, signaling, and chemistry inside artificial cells.

Marco Lolaico

Genome Editing Tools

DNA Rewires CRISPR: Cas12 Becomes RNA-Sensing Platform!

May 28, 2026

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6 min read

DNA Rewires CRISPR: Cas12 Becomes RNA-Sensing Platform!

Pseudo-guide DNA turns Cas12 into a versatile platform for RNA sensing and knockdown.

Marco Lolaico

DNA/RNA Nanotech

Designer RNA Nanostars: Programming Membraneless Organelles!

May 21, 2026

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5 min read

Designer RNA Nanostars: Programming Membraneless Organelles!

RNA nanostars assemble membraneless organelles with tunable composition and behavior.

Marco Lolaico

Synthetic Biology

AI-Designed Protein Switches: ML Creates Allosteric Biosensors!

May 14, 2026

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6 min read

AI-Designed Protein Switches: ML Creates Allosteric Biosensors!

Researchers turn AI-designed binders into allosteric protein switches, creating sensors, logic gates, and programmable cellular responses.

Marco Lolaico

Synthetic Biology

Designed Protein Recorders: Cells Build 3D Memory!

May 7, 2026

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5 min read

Designed Protein Recorders: Cells Build 3D Memory!

A protein-based recorder grows 3D structures inside cells, turning transient signals into molecular "tree-rings" you can image later.

Marco Lolaico

Drug Delivery

Apr 30, 2026

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6 min read

DNA Logic Meets Affibodies: DNA Circuits Enable Smart Drug Delivery!

Researchers combine affibodies with programmable DNA circuits to deliver drugs only when the right markers align.

Marco Lolaico

AI Protein Design

AI-Designed Ultra Strong Proteins: Unbreakable at 150°C!

Apr 23, 2026

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5 min read

AI-Designed Ultra Strong Proteins: Unbreakable at 150°C!

AI-guided design packs force-bearing protein strands with extra hydrogen bonds for extreme stability.

Marco Lolaico

Synthetic Biology

Computer-Powered Virtual Cells: 4D Simulations Model Life at Molecular Level!

Apr 16, 2026

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5 min read

Computer-Powered Virtual Cells: 4D Simulations Model Life at Molecular Level!

A 4D whole-cell model simulates cellular processes across space and time with molecular detail.

Marco Lolaico

DNA/RNA Nanotech

Molecular Hard Drives: DNA Origami Rewrites Data Storage!

Apr 9, 2026

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10 min read

Molecular Hard Drives: DNA Origami Rewrites Data Storage!

DNA origami structures act as storage nodes, encoding data and connections at the nanoscale.

Marco Lolaico

DNA/RNA Nanotech

Synthetic DNA Cells: Synthetic Cytoskeleton Engineering!

Apr 2, 2026

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10 min read

Synthetic DNA Cells: Synthetic Cytoskeleton Engineering!

Synthetic DNA cells recreate the crowded and viscoelastic environment of the cytoplasm.

Marco Lolaico

AI for Genome

AI-Designed Genomes: Evo 2 Unlocks Genome-Scale DNA!

Mar 26, 2026

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10 min read

AI-Designed Genomes: Evo 2 Unlocks Genome-Scale DNA!

Trained on trillions of DNA bases, a genomic foundation model predicts mutations and generates new genomes.

Marco Lolaico

Drug Delivery

mRNA-Launched Vaccines: mRNA and Protein Nanostructures for Immune Breakthrough!

Mar 19, 2026

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9 min read

mRNA-Launched Vaccines: mRNA and Protein Nanostructures for Immune Breakthrough!

mRNA-launched vaccines merge intracellular expression with the potency of protein nanostructures.

Marco Lolaico