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Oliver Buchannon
Marco Lolaico

DNA nanotech researcher, writing Plenty of Room to always bring you the coolest papers!

Synthetic Biology

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AI-Designed Protein Switches: ML Creates Allosteric Biosensors!

May 14, 2026

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6 min read

AI-Designed Protein Switches: ML Creates Allosteric Biosensors!

Researchers turn AI-designed binders into allosteric protein switches, creating sensors, logic gates, and programmable cellular responses.

Marco Lolaico
Marco Lolaico

Synthetic Biology

Designed Protein Recorders: Cells Build 3D Memory!

May 7, 2026

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5 min read

Designed Protein Recorders: Cells Build 3D Memory!

A protein-based recorder grows 3D structures inside cells, turning transient signals into molecular "tree-rings" you can image later.

Marco Lolaico
Marco Lolaico

Drug delivery

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DNA Logic Meets Affibodies: DNA Circuits Enable Smart Drug Delivery!

Apr 30, 2026

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6 min read

DNA Logic Meets Affibodies: DNA Circuits Enable Smart Drug Delivery!

Researchers combine affibodies with programmable DNA circuits to deliver drugs only when the right markers align.

Marco Lolaico
Marco Lolaico

AI protein design

AI-Designed Ultra Strong Proteins: Unbreakable at 150°C!

Apr 23, 2026

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5 min read

AI-Designed Ultra Strong Proteins: Unbreakable at 150°C!

AI-guided design packs force-bearing protein strands with extra hydrogen bonds for extreme stability.

Marco Lolaico
Marco Lolaico

Synthetic Biology

Computer-Powered Virtual Cells: 4D Simulations Model Life at Molecular Level!

Apr 16, 2026

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5 min read

Computer-Powered Virtual Cells: 4D Simulations Model Life at Molecular Level!

A 4D whole-cell model simulates cellular processes across space and time with molecular detail.

Marco Lolaico
Marco Lolaico

DNA/RNA nanotech

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Molecular Hard Drives: DNA Origami Rewrites Data Storage!

Apr 9, 2026

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10 min read

Molecular Hard Drives: DNA Origami Rewrites Data Storage!

DNA origami structures act as storage nodes, encoding data and connections at the nanoscale.

Marco Lolaico
Marco Lolaico

DNA/RNA nanotech

+1

Synthetic DNA Cells: Synthetic Cytoskeleton Engineering!

Apr 2, 2026

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10 min read

Synthetic DNA Cells: Synthetic Cytoskeleton Engineering!

Synthetic DNA cells recreate the crowded and viscoelastic environment of the cytoplasm.

Marco Lolaico
Marco Lolaico

AI for genome

AI-Designed Genomes: Evo 2 Unlocks Genome-Scale DNA!

Mar 26, 2026

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10 min read

AI-Designed Genomes: Evo 2 Unlocks Genome-Scale DNA!

Trained on trillions of DNA bases, a genomic foundation model predicts mutations and generates new genomes.

Marco Lolaico
Marco Lolaico

Drug delivery

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mRNA-Launched Vaccines: mRNA and Protein Nanostructures for Immune Breakthrough!

Mar 19, 2026

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9 min read

mRNA-Launched Vaccines: mRNA and Protein Nanostructures for Immune Breakthrough!

mRNA-launched vaccines merge intracellular expression with the potency of protein nanostructures.

Marco Lolaico
Marco Lolaico

Synthetic Biology

Biological Quantum Sensors: Fluorescent Proteins Transform Biology!

Mar 12, 2026

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10 min read

Biological Quantum Sensors: Fluorescent Proteins Transform Biology!

Directed evolution converts a fluorescent protein into a genetically encoded quantum sensor.

Marco Lolaico
Marco Lolaico

Drug delivery

+1

DNA Origami Boosts Anti-HIV Antibodies: Vaccine Breakthrough!

Mar 5, 2026

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10 min read

DNA Origami Boosts Anti-HIV Antibodies: Vaccine Breakthrough!

DNA origami enhances production of rare anti-HIV antibodies by rewiring immune competition.

Marco Lolaico
Marco Lolaico

Genome Editing Tools

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Armored Viruses: Mineral Shells Deliver RNA Editors to Treat Sepsis!

Feb 26, 2026

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10 min read

Armored Viruses: Mineral Shells Deliver RNA Editors to Treat Sepsis!

Mineral shells help viruses evade immunity, deliver RNA editors, and treat sepsis in mice

Marco Lolaico
Marco Lolaico

DNA/RNA nanotech

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Designer RNA Tiles: Programmable Nanostructures Inside Cell Nuclei!

Feb 19, 2026

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8 min read

Designer RNA Tiles: Programmable Nanostructures Inside Cell Nuclei!

Programmable RNA structures assemble inside living cell nuclei

Marco Lolaico
Marco Lolaico

Synthetic Biology

RNA TimeVaults: Capturing Cellular Decision Dynamics!

Feb 12, 2026

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9 min read

RNA TimeVaults: Capturing Cellular Decision Dynamics!

A molecular hard drive engineered to store RNA states in living cells.

Marco Lolaico
Marco Lolaico

Synthetic Biology

Sidewinder Rewrites DNA Assembly Rules With Designed DNA Junctions!

Feb 5, 2026

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10 min read

Sidewinder Rewrites DNA Assembly Rules With Designed DNA Junctions!

A new assembly method builds complex DNA without sequence or length constraints

Marco Lolaico
Marco Lolaico

DNA/RNA nanotech

DNA Origami Needles: Virus-Inspired Nanostructures for Drug Delivery!

Jan 29, 2026

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10 min read

DNA Origami Needles: Virus-Inspired Nanostructures for Drug Delivery!

Engineering Virus-Like Delivery Using Programmable DNA Structures

Marco Lolaico
Marco Lolaico

AI protein design

AI-Designed Enzyme Atoms: RFdiffusion2 Crafts Catalytic Proteins!

Jan 22, 2026

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11 min read

AI-Designed Enzyme Atoms: RFdiffusion2 Crafts Catalytic Proteins!

Designing functional enzymes by placing catalytic atoms with RFdiffusion2

Marco Lolaico
Marco Lolaico

Genome Editing Tools

Epigenetic Editors: CRISPR's Geneless Gene Control Revolution!

Jan 15, 2026

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10 min read

Epigenetic Editors: CRISPR's Geneless Gene Control Revolution!

How a new delivery system and epigenetic editors control genes without cutting DNA

Marco Lolaico
Marco Lolaico

AI protein design

AI-Designed Enzyme Engineering: Machine Learning Catalyzes Biotech Breakthroughs!

Jan 8, 2026

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10 min read

AI-Designed Enzyme Engineering: Machine Learning Catalyzes Biotech Breakthroughs!

How catalytic motifs and protein backbones can be assembled into functional enzymes from scratch

Marco Lolaico
Marco Lolaico

DNA/RNA nanotech

DNA Trivalent Binders: DNA Nanotechnology Meets Viral Geometry!

Jan 2, 2026

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10 min read

DNA Trivalent Binders: DNA Nanotechnology Meets Viral Geometry!

Evolving trivalent DNA binders to match viral protein geometry

Marco Lolaico
Marco Lolaico
2025 Wrapped

Dec 23, 2025

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8 min read

2025 Wrapped

The "best" articles of the year!

Marco Lolaico
Marco Lolaico

Synthetic Biology

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AI-Designed DNA Binders: Machine Learning Crafts Novel Proteins!

Dec 18, 2025

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10 min read

AI-Designed DNA Binders: Machine Learning Crafts Novel Proteins!

Designing sequence-specific DNA-binding proteins entirely from scratch

Marco Lolaico
Marco Lolaico

DNA/RNA nanotech

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DNA Origami Membranes: Molecular Mimicry Rewrites Cellular Architecture!

Dec 11, 2025

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10 min read

DNA Origami Membranes: Molecular Mimicry Rewrites Cellular Architecture!

Engineered DNA barrels self-organize into flexible monolayers that behave like synthetic membranes.

Marco Lolaico
Marco Lolaico

AI for genome

AI-Born Genes: Machine Learning Rewrites Genomics!

Dec 4, 2025

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10 min read

AI-Born Genes: Machine Learning Rewrites Genomics!

How a Genomic Foundation Model Turns Evolutionary Patterns into Brand-New Functional Genes

Marco Lolaico
Marco Lolaico

Synthetic Biology

+1

Cell-Electronics Hybrids: Immune Cells For Neural Modulation!

Nov 27, 2025

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10 min read

Cell-Electronics Hybrids: Immune Cells For Neural Modulation!

Immune cells carry micro-circuits into the brain for neural activation, with no surgery.

Marco Lolaico
Marco Lolaico
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